Demographics

PACC Sample

Characteristic

N

Overall, N = 1,7371

A4, N = 4591

LEARN, N = 3111

SF, N = 9671

Baseline Age

1,737

71.31 (4.70)
[64.63, 85.89]

71.97 (4.81)
[65.00, 85.51]

70.36 (4.31)
[65.00, 84.46]

71.30 (4.72)
[64.63, 85.89]

Sex

1,737

Female

1,083 (62.35%)

291 (63.40%)

189 (60.77%)

603 (62.36%)

Male

654 (37.65%)

168 (36.60%)

122 (39.23%)

364 (37.64%)

Years of Education

1,737

16.55 (2.75)
[7.00, 32.00]

16.56 (2.72)
[7.00, 30.00]

16.57 (2.46)
[9.00, 27.00]

16.54 (2.86)
[10.00, 32.00]

APOEe4 Status

1,715

e4-

1,116 (65.07%)

193 (42.05%)

232 (75.08%)

691 (72.97%)

e4+

599 (34.93%)

266 (57.95%)

77 (24.92%)

256 (27.03%)

PACC Score

1,737

-0.81 (2.33)
[-12.08, 5.58]

-1.15 (2.43)
[-11.15, 5.17]

-0.71 (2.24)
[-6.79, 4.38]

-0.68 (2.31)
[-12.08, 5.58]

Baseline Amyloid Status

1,737

Ab-

1,278 (73.58%)

0 (0.00%)

311 (100.00%)

967 (100.00%)

Ab+

459 (26.42%)

459 (100.00%)

0 (0.00%)

0 (0.00%)

Baseline Global Amyloid Burden

1,737

1.09 (0.19)
[0.79, 2.00]

1.33 (0.16)
[1.01, 2.00]

0.99 (0.07)
[0.79, 1.15]

1.01 (0.11)
[0.81, 1.84]

Treatment Group

1,737

A4 Placebo

236 (13.59%)

236 (51.42%)

0 (0.00%)

0 (0.00%)

A4 Treated

223 (12.84%)

223 (48.58%)

0 (0.00%)

0 (0.00%)

LEARN/SF

1,278 (73.58%)

0 (0.00%)

311 (100.00%)

967 (100.00%)

1Mean (SD)
[Range]; n (%)

Demographics for participants with at least two PACC visits

Characteristic

N

Overall, N = 7711

A4, N = 4591

LEARN, N = 3111

SF, N = 11

Baseline Age

771

71.33 (4.68)
[65.00, 85.51]

71.97 (4.81)
[65.00, 85.51]

70.36 (4.31)
[65.00, 84.46]

77.34 (NA)
[77.34, 77.34]

Sex

771

Female

481 (62.39%)

291 (63.40%)

189 (60.77%)

1 (100.00%)

Male

290 (37.61%)

168 (36.60%)

122 (39.23%)

0 (0.00%)

Years of Education

771

16.57 (2.61)
[7.00, 30.00]

16.56 (2.72)
[7.00, 30.00]

16.57 (2.46)
[9.00, 27.00]

16.00 (NA)
[16.00, 16.00]

APOEe4 Status

769

e4-

425 (55.27%)

193 (42.05%)

232 (75.08%)

0 (0.00%)

e4+

344 (44.73%)

266 (57.95%)

77 (24.92%)

1 (100.00%)

PACC Score

771

-0.97 (2.36)
[-11.15, 5.17]

-1.15 (2.43)
[-11.15, 5.17]

-0.71 (2.24)
[-6.79, 4.38]

0.25 (NA)
[0.25, 0.25]

Baseline Amyloid Status

771

Ab-

312 (40.47%)

0 (0.00%)

311 (100.00%)

1 (100.00%)

Ab+

459 (59.53%)

459 (100.00%)

0 (0.00%)

0 (0.00%)

Baseline Global Amyloid Burden

771

1.19 (0.21)
[0.79, 2.00]

1.33 (0.16)
[1.01, 2.00]

0.99 (0.07)
[0.79, 1.15]

1.18 (NA)
[1.18, 1.18]

Treatment Group

771

A4 Placebo

236 (30.61%)

236 (51.42%)

0 (0.00%)

0 (0.00%)

A4 Treated

223 (28.92%)

223 (48.58%)

0 (0.00%)

0 (0.00%)

LEARN/SF

312 (40.47%)

0 (0.00%)

311 (100.00%)

1 (100.00%)

PACC Timepoints

771

12.07 (4.12)
[2.00, 18.00]

12.31 (4.08)
[2.00, 18.00]

11.75 (4.13)
[2.00, 18.00]

2.00 (NA)
[2.00, 2.00]

PACC Years of Follow Up

745

5.27 (2.05)
[0.12, 7.60]

5.25 (1.96)
[0.18, 7.46]

5.31 (2.16)
[0.12, 7.60]

0.33 (NA)
[0.33, 0.33]

1Mean (SD)
[Range]; n (%)

Amyloid Sample

Characteristic

N

Overall, N = 1,7371

A4, N = 4591

LEARN, N = 3111

SF, N = 9671

Baseline Age

1,737

71.31 (4.70)
[64.63, 85.89]

71.97 (4.81)
[65.00, 85.51]

70.36 (4.31)
[65.00, 84.46]

71.30 (4.72)
[64.63, 85.89]

Sex

1,737

Female

1,083 (62.35%)

291 (63.40%)

189 (60.77%)

603 (62.36%)

Male

654 (37.65%)

168 (36.60%)

122 (39.23%)

364 (37.64%)

Years of Education

1,737

16.55 (2.75)
[7.00, 32.00]

16.56 (2.72)
[7.00, 30.00]

16.57 (2.46)
[9.00, 27.00]

16.54 (2.86)
[10.00, 32.00]

APOEe4 Status

1,715

e4-

1,116 (65.07%)

193 (42.05%)

232 (75.08%)

691 (72.97%)

e4+

599 (34.93%)

266 (57.95%)

77 (24.92%)

256 (27.03%)

PACC Score

1,737

-0.81 (2.33)
[-12.08, 5.58]

-1.15 (2.43)
[-11.15, 5.17]

-0.71 (2.24)
[-6.79, 4.38]

-0.68 (2.31)
[-12.08, 5.58]

Baseline Amyloid Status

1,737

Ab-

1,278 (73.58%)

0 (0.00%)

311 (100.00%)

967 (100.00%)

Ab+

459 (26.42%)

459 (100.00%)

0 (0.00%)

0 (0.00%)

Baseline Global Amyloid Burden

1,737

1.09 (0.19)
[0.79, 2.00]

1.33 (0.16)
[1.01, 2.00]

0.99 (0.07)
[0.79, 1.15]

1.01 (0.11)
[0.81, 1.84]

Treatment Group

1,737

A4 Placebo

236 (13.59%)

236 (51.42%)

0 (0.00%)

0 (0.00%)

A4 Treated

223 (12.84%)

223 (48.58%)

0 (0.00%)

0 (0.00%)

LEARN/SF

1,278 (73.58%)

0 (0.00%)

311 (100.00%)

967 (100.00%)

1Mean (SD)
[Range]; n (%)

Demographics for participants with at least two amyloid scans

Characteristic

N

Overall, N = 5361

A4, N = 3671

LEARN, N = 1691

Baseline Age

536

71.17 (4.59)
[65.00, 85.26]

71.77 (4.68)
[65.00, 85.26]

69.88 (4.13)
[65.00, 81.73]

Sex

536

Female

346 (64.55%)

237 (64.58%)

109 (64.50%)

Male

190 (35.45%)

130 (35.42%)

60 (35.50%)

Years of Education

536

16.55 (2.52)
[7.00, 27.00]

16.50 (2.63)
[7.00, 27.00]

16.65 (2.26)
[12.00, 21.00]

APOEe4 Status

535

e4-

283 (52.90%)

148 (40.33%)

135 (80.36%)

e4+

252 (47.10%)

219 (59.67%)

33 (19.64%)

PACC Score

536

-0.84 (2.40)
[-11.15, 5.17]

-1.05 (2.44)
[-11.15, 5.17]

-0.38 (2.26)
[-6.73, 4.38]

Baseline Amyloid Status

536

Ab-

169 (31.53%)

0 (0.00%)

169 (100.00%)

Ab+

367 (68.47%)

367 (100.00%)

0 (0.00%)

Baseline Global Amyloid Burden

536

1.23 (0.21)
[0.83, 2.00]

1.33 (0.16)
[1.01, 2.00]

0.99 (0.07)
[0.83, 1.15]

Treatment Group

536

A4 Placebo

189 (35.26%)

189 (51.50%)

0 (0.00%)

A4 Treated

178 (33.21%)

178 (48.50%)

0 (0.00%)

LEARN/SF

169 (31.53%)

0 (0.00%)

169 (100.00%)

PACC Timepoints

536

13.94 (2.68)
[3.00, 18.00]

13.66 (2.93)
[3.00, 18.00]

14.56 (1.90)
[9.00, 18.00]

PACC Years of Follow Up

518

6.13 (1.30)
[0.42, 7.60]

5.89 (1.40)
[0.42, 7.46]

6.70 (0.78)
[4.36, 7.60]

1Mean (SD)
[Range]; n (%)

TAU Sample

Characteristic

N

Overall, N = 2441

A4, N = 1961

LEARN, N = 461

SF, N = 21

Baseline Age

244

71.65 (4.74)
[65.00, 85.51]

72.11 (4.64)
[65.00, 85.51]

69.47 (4.53)
[65.08, 84.46]

77.04 (4.29)
[74.00, 80.07]

Sex

244

Female

153 (62.70%)

127 (64.80%)

26 (56.52%)

0 (0.00%)

Male

91 (37.30%)

69 (35.20%)

20 (43.48%)

2 (100.00%)

Years of Education

244

16.34 (2.74)
[9.00, 30.00]

16.26 (2.82)
[9.00, 30.00]

16.74 (2.39)
[12.00, 20.00]

16.00 (0.00)
[16.00, 16.00]

APOEe4 Status

244

e4-

120 (49.18%)

87 (44.39%)

33 (71.74%)

0 (0.00%)

e4+

124 (50.82%)

109 (55.61%)

13 (28.26%)

2 (100.00%)

PACC Score

244

-1.06 (2.59)
[-11.15, 5.17]

-1.26 (2.51)
[-11.15, 5.17]

0.02 (2.47)
[-6.33, 4.38]

-5.74 (4.12)
[-8.66, -2.83]

Baseline Amyloid Status

244

Ab-

48 (19.67%)

0 (0.00%)

46 (100.00%)

2 (100.00%)

Ab+

196 (80.33%)

196 (100.00%)

0 (0.00%)

0 (0.00%)

Baseline Global Amyloid Burden

244

1.28 (0.20)
[0.86, 1.85]

1.34 (0.16)
[1.05, 1.85]

1.00 (0.06)
[0.86, 1.11]

1.60 (0.02)
[1.58, 1.61]

Treatment Group

244

A4 Placebo

100 (40.98%)

100 (51.02%)

0 (0.00%)

0 (0.00%)

A4 Treated

96 (39.34%)

96 (48.98%)

0 (0.00%)

0 (0.00%)

LEARN/SF

48 (19.67%)

0 (0.00%)

46 (100.00%)

2 (100.00%)

1Mean (SD)
[Range]; n (%)

Demographics for participants with at least two tau scans

Characteristic

N

Overall, N = 2171

A4, N = 1741

LEARN, N = 431

Baseline Age

217

71.59 (4.68)
[65.00, 85.51]

72.10 (4.57)
[65.00, 85.51]

69.54 (4.63)
[65.08, 84.46]

Sex

217

Female

137 (63.13%)

112 (64.37%)

25 (58.14%)

Male

80 (36.87%)

62 (35.63%)

18 (41.86%)

Years of Education

217

16.35 (2.73)
[11.00, 30.00]

16.26 (2.80)
[11.00, 30.00]

16.70 (2.43)
[12.00, 20.00]

APOEe4 Status

217

e4-

109 (50.23%)

78 (44.83%)

31 (72.09%)

e4+

108 (49.77%)

96 (55.17%)

12 (27.91%)

PACC Score

217

-1.05 (2.57)
[-11.15, 5.17]

-1.30 (2.55)
[-11.15, 5.17]

-0.04 (2.45)
[-6.33, 4.38]

Baseline Amyloid Status

217

Ab-

43 (19.82%)

0 (0.00%)

43 (100.00%)

Ab+

174 (80.18%)

174 (100.00%)

0 (0.00%)

Baseline Global Amyloid Burden

217

1.27 (0.20)
[0.86, 1.85]

1.34 (0.16)
[1.07, 1.85]

1.00 (0.06)
[0.86, 1.11]

Treatment Group

217

A4 Placebo

87 (40.09%)

87 (50.00%)

0 (0.00%)

A4 Treated

87 (40.09%)

87 (50.00%)

0 (0.00%)

LEARN/SF

43 (19.82%)

0 (0.00%)

43 (100.00%)

PACC Timepoints

217

13.65 (2.63)
[6.00, 18.00]

13.79 (2.55)
[6.00, 18.00]

13.07 (2.87)
[6.00, 17.00]

PACC Years of Follow Up

208

5.97 (1.26)
[1.88, 7.56]

5.96 (1.19)
[1.88, 7.46]

6.05 (1.56)
[2.06, 7.56]

1Mean (SD)
[Range]; n (%)

pTAU Sample

Characteristic

N

Overall, N = 7241

A4, N = 4451

LEARN, N = 2791

Baseline Age

724

71.29 (4.70)
[65.00, 85.51]

71.98 (4.83)
[65.00, 85.51]

70.19 (4.27)
[65.00, 84.46]

Sex

724

Female

457 (63.12%)

284 (63.82%)

173 (62.01%)

Male

267 (36.88%)

161 (36.18%)

106 (37.99%)

Years of Education

724

16.53 (2.60)
[7.00, 30.00]

16.53 (2.71)
[7.00, 30.00]

16.53 (2.42)
[9.00, 26.00]

APOEe4 Status

723

e4-

398 (55.05%)

187 (42.02%)

211 (75.90%)

e4+

325 (44.95%)

258 (57.98%)

67 (24.10%)

PACC Score

724

-0.92 (2.38)
[-11.15, 5.17]

-1.14 (2.45)
[-11.15, 5.17]

-0.57 (2.23)
[-6.73, 4.38]

Baseline Amyloid Status

724

Ab-

279 (38.54%)

0 (0.00%)

279 (100.00%)

Ab+

445 (61.46%)

445 (100.00%)

0 (0.00%)

Baseline Global Amyloid Burden

724

1.20 (0.21)
[0.83, 2.00]

1.33 (0.16)
[1.01, 2.00]

1.00 (0.07)
[0.83, 1.15]

Treatment Group

724

A4 Placebo

228 (31.49%)

228 (51.24%)

0 (0.00%)

A4 Treated

217 (29.97%)

217 (48.76%)

0 (0.00%)

LEARN/SF

279 (38.54%)

0 (0.00%)

279 (100.00%)

1Mean (SD)
[Range]; n (%)

Demographics for participants with at least two ptau visits

Characteristic

N

Overall, N = 5981

A4, N = 4261

LEARN, N = 1721

Baseline Age

598

71.41 (4.72)
[65.00, 85.51]

72.03 (4.85)
[65.00, 85.51]

69.90 (4.01)
[65.00, 82.00]

Sex

598

Female

382 (63.88%)

272 (63.85%)

110 (63.95%)

Male

216 (36.12%)

154 (36.15%)

62 (36.05%)

Years of Education

598

16.58 (2.60)
[7.00, 30.00]

16.52 (2.74)
[7.00, 30.00]

16.72 (2.24)
[12.00, 21.00]

APOEe4 Status

598

e4-

321 (53.68%)

183 (42.96%)

138 (80.23%)

e4+

277 (46.32%)

243 (57.04%)

34 (19.77%)

PACC Score

598

-0.87 (2.42)
[-11.15, 5.17]

-1.11 (2.45)
[-11.15, 5.17]

-0.29 (2.25)
[-6.73, 4.38]

Baseline Amyloid Status

598

Ab-

172 (28.76%)

0 (0.00%)

172 (100.00%)

Ab+

426 (71.24%)

426 (100.00%)

0 (0.00%)

Baseline Global Amyloid Burden

598

1.23 (0.21)
[0.83, 2.00]

1.33 (0.16)
[1.01, 2.00]

0.99 (0.07)
[0.83, 1.15]

Treatment Group

598

A4 Placebo

220 (36.79%)

220 (51.64%)

0 (0.00%)

A4 Treated

206 (34.45%)

206 (48.36%)

0 (0.00%)

LEARN/SF

172 (28.76%)

0 (0.00%)

172 (100.00%)

PACC Timepoints

598

13.06 (3.54)
[2.00, 18.00]

12.58 (3.85)
[2.00, 18.00]

14.26 (2.17)
[7.00, 18.00]

PACC Years of Follow Up

580

5.69 (1.74)
[0.18, 7.60]

5.35 (1.86)
[0.18, 7.46]

6.57 (0.95)
[3.08, 7.60]

1Mean (SD)
[Range]; n (%)